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Separating The Therapeutic Benefits Of Cannabis From Its Mood-altering Side-effects

November 30th, 2007 by admin

Scientists from Queen Mary, University of London, have discovered a new way to separate the therapeutic benefits of cannabis from its mood-altering side-effects.

Cannabis contains a chemical called THC, which binds to, and activates, proteins in the brain known as 'CB1 cannabinoid receptors'. Activating these receptors can relieve pain and prevent epileptic seizures; but it also causes the mood-altering effect experienced by people who use cannabis as a recreational drug. (Credit: iStockphoto/Dmitriy Norov)

Cannabis contains a chemical called THC, which binds to, and activates, proteins in the brain known as ‘CB1 cannabinoid receptors’. Activating these receptors can relieve pain and prevent epileptic seizures; but it also causes the mood-altering effect experienced by people who use cannabis as a recreational drug.

Now, Professor Maurice Elphick and Dr Michaela Egertová from Queen Mary’s School of Biological and Chemical Sciences may have found a way of separating out the effects of cannabis – a discovery which could lead to the development of new medicines to treat conditions such as epilepsy, obesity and chronic pain. The research is described in the December issue of the journal Molecular Pharmacology.

Working in collaboration with scientists based in the USA*, they have identified a protein that binds to the CB1 receptors in the brain. But unlike THC, this ‘Cannabinoid Receptor Interacting Protein’ or CRIP1a, suppresses the activity of CB1 receptors.

Professor Elphick explains: “Because CRIP1a inhibits the activity of the brain’s cannabinoid receptors, it may be possible to develop drugs that block this interaction, and in turn enhance CB1 activity. This may give patients the pain relief associated with CB1 activity, without the ‘high’ that cannabis users experience.”

Leslie Iversen FRS, Professor of Pharmacology at the University of Oxford and author of The Science of Marijuana, commented on the new findings: “This interesting discovery provides a completely new insight into the regulation of the cannabinoid system in the brain - and could offer a new approach to the discovery of cannabis-based medicines in the future.”

Mol Pharmacol. 2007 Dec;72(6):1557-66. Epub 2007 Sep 25.

CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.

Niehaus JL, Liu Y, Wallis KT, Egertová M, Bhartur SG, Mukhopadhyay S, Shi S, He H, Selley DE, Howlett AC, Elphick MR, Lewis DL.

Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA.

The CB1 cannabinoid receptor is a G-protein coupled receptor that has important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection. We report the discovery of two structurally related CB1 cannabinoid receptor interacting proteins (CRIP1a and CRIP1b) that bind to the distal C-terminal tail of CB1. CRIP1a and CRIP1b are generated by alternative splicing of a gene located on chromosome 2 in humans, and orthologs of CRIP1a occur throughout the vertebrates, whereas CRIP1b seems to be unique to primates. CRIP1a coimmunoprecipitates with CB1 receptors derived from rat brain homogenates, indicating that CRIP1a and CB1 interact in vivo. Furthermore, in superior cervical ganglion neurons coinjected with CB1 and CRIP1a or CRIP1b cDNA, CRIP1a, but not CRIP1b, suppresses CB1-mediated tonic inhibition of voltage-gated Ca2+ channels. Discovery of CRIP1a provides the basis for a new avenue of research on mechanisms of CB1 regulation in the nervous system and may lead to development of novel drugs to treat disorders where modulation of CB1 activity has therapeutic potential (e.g., chronic pain, obesity, and epilepsy).

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Research: Benefit of Ribose in a Patient With Fibromyalgia

November 30th, 2007 by admin

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Research: Benefit of Ribose in a Patient With Fibromyalgia

01-31-2005 Journal: Pharmacotherapy
Benjamin Gebhart, Pharm.D.; James A. Jorgenson, M.S., FASHP

Abstract and Introduction
Abstract
Ribose was added to the existing treatment regimen of a woman with fibromyalgia, resulting in a decrease in symptoms. It has been postulated that patients with fibromyalgia may have an alteration in muscle adenine nucleotide metabolism, leading to depleted energy reserves and an imbalance in cellular adenosine-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge. As a key component in adenine nucleotide synthesis, ribose supplementation may be useful in such patients.

Introduction
Fibromyalgia is a syndrome that is manifested by generalized muscle pain and additional systemic symptoms of fatigue, tenderness and stiffness in multiple joints, sleep disturbance, and alterations in bowel activity.

The specific etiology is unknown; however, changes in muscle histology, energy metabolism, oxygen utilization, and the neuroendocrine stress-response system have been postulated to play a role in the development and persistence of this disorder.[1] Low levels of muscle adenine nucleotides, reflected in depleted energy reserves and an imbalance in cellular adenosine 5'-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge, have been reported.[2-4] The unknown cause and varying presenting symptoms make fibromyalgia a therapeutic challenge for practitioners.[5-7]

The management of patients with fibromyalgia requires the integration of both pharmacologic and nonpharmacologic approaches. Pharmacologic options have included tricyclic antidepressants, selective serotonin receptor antagonists, analgesics, benzodiazepines, antiinflammatory agents, and corticosteroids.[5, 6, 8]

Routine daily exercise programs, dietary modifications, alternative therapies such as biofeedback and hypnotherapy, and nutraceuticals such as S-adenosyl-L-methionine (SAMe) have also been explored.[9] Unfortunately, less than 50% of patients achieve any meaningful relief of their symptoms with use of those therapies.[5]

We describe the case of a patient with fibromyalgia who had symptomatic relief when ribose was added to her existing treatment regimen. There have been anecdotal reports on the benefits of ribose in patients with fibromyalgia in whom conventional therapies have failed; however, to our knowledge, this is the first published case of use of ribose for this syndrome.

Case Report
A 37-year-old woman had daily episodes of intense musculoskeletal pain and stiffness, mental "cloudiness," bouts of diarrhea, and sleep disturbance. As she was a surgeon, these symptoms compromised the skills necessary to perform her daily duties in the operating room. She was diagnosed with fibromyalgia by exclusion of other diseases and syndromes and in accordance with the American College of Rheumatology criteria.[10]

The patient was treated with ibuprofen 800 mg twice/day, valdecoxib 10 mg once/day, diphenhydramine 50 mg-acetaminophen 1000 mg at bedtime, and physical therapy once/day. She stated that this therapeutic regimen had limited benefit and that the adverse effects from these drugs further impaired her ability to perform her operative duties.

Approximately 7 months later, in addition to her regular drug therapy, the patient began taking CORvalen (Bioenergy, Inc., Ham Lake, MN), a ribose-based product. She took 5 g of CORvalen mixed in water twice/day. She experienced no adverse effects, and after 14 days she reported a decrease in her symptoms. Specifically, she noted an improvement in sleep, mental alertness, a marked decrease in joint pain, and normal stools. This trend continued, and after an additional month of CORvalen therapy she reported near-normal functioning with a major reduction in her symptoms.

After another month of taking CORvalen and feeling "normal," the patient elected to discontinue the drug. Within 7 days, she regressed to her initial fibromyalgia state, as reflected in joint pain, sleep disturbance, morning stiffness, trigger-point flares, and diarrhea. She resumed taking CORvalen, at the same dosage as before, and a major reduction in her symptoms again occurred within 14 days. She noted continual benefit for the next month while taking CORvalen. She stopped taking the drug for a second time after this additional 30-day period, and once again she experienced a reemergence of symptoms. When CORvalen was restarted for a third time, the patient's symptoms again subsided.

At the time of this writing, the patient was continuing to take CORvalen and was satisfied that her symptoms had abated.

Discussion
Ribose is a simple carbohydrate that plays a role in high-energy phosphate and nucleic acid synthesis. After ischemia or hypoxia, myocytes have decreased levels of ATP and total adenine nucleotides. Several days are required for their recovery once normoxia has been reestablished.[11-13] In patients with chronic hypoxic conditions, the cellular energy charge may never be fully regained.[14]

These cells have the capacity to regenerate ATP; however, the pentose phosphate pathway of glucose metabolism utilized in the formation of the ribose that is needed to drive the regenerative process is slow in both heart and skeletal muscle cells due to poor expression of specific rate-limiting enzymes. Supplemental ribose has been shown to enhance the synthesis of adenine nucleotides, rebuilding depressed energy pools in both the heart and skeletal muscle after an ischemic or hypoxic insult.[11, 12] Ribose bypasses the rate-limiting enzymatic steps of the pentose phosphate pathway and accelerates the formation of ATP and subsequent tissue recovery.[15]

Supplemental ribose is initially converted to ribose-5-phosphate, subsequently forming 5-phosphoribosyl-1-pyrophosphate, a molecule key to the synthesis of ATP through the de novo purine nucleotide pathway. The safety of ribose has been investigated in standard laboratory and animal toxicology models and in human studies both subjectively and objectively. Investigators have concluded that ribose is well tolerated at dosages of up to 60 g/day, with no significant adverse effects.[16]

Ribose has been shown to improve the energy recovery time in skeletal muscle and to relieve fatigue, soreness, and stiffness after intense exercise.[12, 13, 17] It also has been reported to have a beneficial effect after high-intensity exercise in sports medicine.

One study concluded that ribose accelerated the replenishment of ATP after intense muscle contractions,[18] and bodybuilders and sprinters have reported subjective and objective benefits during exercise after the administration of ribose.[18-20] However, other reports have shown inconsistent results for ribose in relation to improving short-term anaerobic exercise performance, muscle strength, endurance, or body composition during cycling or resistance training.[20, 21]

Ribose has also been investigated for its potential medical efficacy in both animal studies and human clinical trials. To date, the most promising data have been reported in connection with the application of ribose in cardiovascular disease. Both short-term and long-term animal studies found that the use of ribose after myocardial ischemia resulted in enhanced recovery of ATP along with improved diastolic functional parameters.[22, 23]

Clinical benefits have also been observed. Patients with coronary artery disease or heart failure have decreased myocardial ATP levels. Daily supplemental ribose has been shown to improve cardiac function, increase exercise tolerance, and enhance quality of life in this population.[24]

Patients with fibromyalgia may experience an alteration in physiologic muscle metabolism. It has been found that they reach the anaerobic threshold in their muscles earlier, thereby using less of the available energy-rich phosphate metabolites at maximal work capacity.[25] In another study, patients with fibromyalgia were reported to have a potential abnormality in high-energy phosphate metabolism, as evidenced by significantly lower levels of ATP and ADP in affected muscles as compared with patients without the disease.[2]

Theoretically, the effect of ribose on increasing the muscle energy pool could reduce the metabolic strain in affected muscles and allow patients to assume a more active lifestyle. Considering the known musculoskeletal symptomatology in this syndrome and the reported benefits of ribose in skeletal muscle metabolism and physiology, supplemental ribose appears to have aided our patient in improving her quality of life.

Conclusion
Fibromyalgia presents a continuing therapeutic challenge. Ribose is a naturally occurring carbohydrate with documented medical benefits in patients with cardiovascular disease. To our knowledge, this is the first report to suggest its potential benefit in a patient with fibromyalgia, who had had suboptimal results with conventional therapies. We are designing a trial using objective outcome measures to further evaluate the effectiveness of this product in patients with fibromyalgia

Pharmacotherapy 24(11):1646-1648, 2004. © 2004 Pharmacotherapy Publications
References:
1. Olson NJ, Park JH. Skeletal muscle abnormalities in patients with fibromyalgia. Am J Med Sci 1998;315:351-8.
2. Bengtsson A, Henriksson KG, Larsson J. Reduced high-energy phosphate levels in the painful muscles of patients with primary fibromyalgia. Arthritis Rheum 1986;29:817-21.
3. Eisinger J, Plantamura A, Ayavou T. Glycolysis abnormalities in fibromyalgia. J Am Coll Nutr 1994;13:144-8.
4. Park JH, Phothimat P, Oates CT, Hernaz-Schulman M, Olsen NJ. Use of P-31 magnetic resonance spectroscopy to detect metabolic abnormalities in muscles of patients with fibromyalgia. Arthritis Rheum 1998;41:406-13.
5. Leventhal LJ. Management of fibromyalgia. Ann Intern Med 1999;131:850-7.
6. Friedberg F, Jason LA. Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment. J Clin Psychol 2001;57:433-55. Lash AA, Ehrlich-Jones L, McCoy D. Fibromyalgia: evolving concepts and management in primary care settings. Medsurg Nurs 2003;12:145-59, 190.
7. Briley M, Moret C. Fibromyalgia syndrome: an overview of potential drug targets. Drugs 2003;6:668-73.
8. Holdcraft LC, Assefi N, Buchwald D. Complementary and alternative medicine in fibromyalgia and related syndromes. Best Pract Res Clin Rheumatol 2003;17:667-83.
9. Wolfe F, for the American College of Rheumatology. Criteria for the classification of fibromyalgia: report of the multi-center criteria committee. Arthritis Rheum 1990;33:160-72.
10. St Cyr J, Bianco R, Schneider J, et al. Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model. J Surg Res 1989;42:157-62.
11. Hellsten Y, Skadhauge L, Bangsbo J. Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. Am J Physiol Integr Comp Physiol 2004;286:R182-8.
12. Williamson DL, Gallagher PM, Goddard MP, Witter J, Trappe S. Effects of ribose supplementation on adenine nucleotide concentration in skeletal muscle following high-intensity exercise [abstr]. Med Sci Sport Exer 2001;33(5 suppl).
13. Ingwall JS. ATP and the heart. Boston: Kluwer Academic, 2002:55-95.
14. Pauly DF, Pepine CJ. D-ribose as a supplement for cardiac energy metabolism. J Cardiovasc Pharmacol Ther 2000;5: 249-58.
15. Pliml W, von Arnim T, Stablein A, Hoffman H, Zimmer HG, Erdmann E. Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
16. Butler T, St Cyr J. Use of ribose to prevent cramps and soreness in muscles. U.S. patent 6159943. December 12, 2000.
17. Zarzeczny R, Brault JJ, Abraham KA, Hancock C, Terjung R. Influence of ribose on adenine salvage after intense muscle contractions. J Appl Physiol 2001;91:1775-81.
18. Van Gammeren D, Antonio J, Falk D. The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational bodybuilders: a double-blind, placebo controlled trial. Cur Therapeut Res 2002;63:486-95.
19. Berandi JM, Ziegenfuss TN. Effects of ribose supplementation on repeated sprint performance in men. J Strength Cond Res 2003;17:47-52.
20. Falk DJ, Heelan KA, Thyfault JP, Koch AJ. Effects of effervescent creatine, ribose, and glutamine supplementation on muscular strength, muscular endurance, and body composition. J Strength Cond Res 2003;17:810-16.
21. Schneider J, St Cyr J, Mahoney J, Bianco R, Ring W, Foker J. Recovery of ATP and return of function after global ischemia [abstr]. Circulation 1985;72(4 pt 2):III-298.
22. Zimmer HG. Normalization of depressed heart function in rats by ribose. Science 1983;220:81-2.
23. Omran H, Illien S, MacCarter D, St Cyr J, Luderitz B. D-ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Failure 2003;5:615-19.
24. Lund E, Kendall SA, Janerot-Sjoberg B, Bengtsson A. Muscle metabolism in fibromyalgia studied by P-31 magnetic resonance spectroscopy during aerobic and anaerobic exercise. Scand J Rheumatol 2003;32:138-45.
Source: MedScape

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Healing pain while we sleep…

November 30th, 2007 by admin

One source of pain is grief, sorrow and mourning from the loss of loved ones who have died. Many people stuff their feelings down and do not know how to deal with their feelings of loss and grief. They feel overwhelmed and push their feelings away. Except that feelings remain alive in our bodies until we release and express them.  Think of the body as a vehicle for our unexpressed emotions (thanks to Lucia Capacchione for this explanation).  Our soul keeps our feelings alive for us in this physical container until we are ready and able and willing to deal and feel. 

One way we can release our feelings is to ask God, Goddess, our Spiritual Guides, Jesus, Buddha, whoever your believe is Divine, to help us while we sleep to release our feelings of loss, grief, mourning and sadness and sorrow.

Another way is to become aware of that there is a whole other dimension to life. Beyond the veil of this dimension.

People receive visitations from the dead all of the time. I have and most of us do. Some of us know this and others are in denial or unaware. The dead live in another dimension from ours. Life is eternal. Love is immortal. Death is only a horizon as Carly Simon said in that song.

Often, the deceased come to us in our dreams to let us know that they are ok and they use the dream format because when they show up in other ways, many people cannot receive or honor their presence. John Edwards has made people more aware that the dead are alive and well and doing fine and want to talk to us. So the dead speak with us to us while we sleep, to reassure us, to comfort us, to soothe us and let us know that they are stlll around.

Years ago, my father came through to me in a very vivid dream, a visitation, and I started doing psychic readings for others. As my gifts grew, the folks from the other side started talking to me, in dreams, in words, in visions, and even through music.

A recent experience: I was driving into Kings Canyon, Sequoia National Park. It was a beautiful warm sunny summer day. As the song came onto the radio. I saw that there were wildflowers everywhere, gorgeous colors. The moment seemed out of normal reality. The song reminded me of an old boyfriend who had always wanted to show me wildflowers. And I wept because I knew this was his way of letting me know he was still around. (I found out last year that he had passed).

Another time, I was doing a writing class with an older woman. She kept talking about everything BUT writing, and any time I could get a word in to change the subject, she interrupted and kept up her monologue. At some point, I saw this young man, brown hair, in his 20's, who told me that he was her son and he had passed from AIDS. He was cracking jokes and finally, I asked her to verify what I was seeing and hearing. You would think that would have gotten her attention, but no, she kept right on. And she confirmed everything he told me about his name, and his dog. I spent the rest of the time listening to her and to him making me laugh. So you just never know who will come through and what they will say.

The first time I am aware of a loved one that I did not know in this life who came through and talked to me for awhile, was my grandmother who I was named after but she had died before I was born. Her name was Celia. She and I chatted while I was watching John Edwards for the first time. I did not know who he was then. Funny that he, James van Praagh and I all come from the same vicinity, in Queens, NYC.

My aunt came to me about a week after she passed. I was returning home from work when I heard her voice loud and clear behind me. I turned around expecting to see her there. She was not visible to my eyes but her voice was audible. Now, she and I have a special code word/name that when I hear or read it, I know that is a message from my auntie. It's funny. Another aunt of mine I have not heard from much since she passed. But one time, I was praying and asking all of my guides and passed over loved ones for assistance. I named this long list of people since most of my relatives are now gone to the other side. A few days later, I saw a license plate with the name Matilda and I laughed out loud because I realized that I had left out my aunt's name and this was her way of letting me know that. Some people might say this is coincidence, I don't think so.

If anyone is interested in doing a reading, just let me know and I will be happy to give you one. What I find is that these readings are a relief and a healing for people.

 
http://greengoddessesguide.googlepages.com/psychicreadings 

 

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Hydrocodone

November 30th, 2007 by admin

There are many documented cases of pharmacists, nurses and doctors diverting drugs for their own use -- specifically hydrocodone.

Here is a case where a pharmacy technician in Christiansburg admitted to diverting some 30 doses of hydrocodone. But after examining at records for the year that Jennifer Hines was employed, the pharmacist in charge at Davidson's Pharmacy ended up filing a DEA report for loss of controlled substances for some 288 dosage units of hydrocodone.

Hines had her license indefinitely suspended by the board.

Hydrocodone is a popular drug for diversion. It is habit forming and used to treat pain. I know people who have used left over doses from an injury to alleviate the effects of a hangover.

According to the U.S. Department of Justice:

"Hydrocodone diversion and abuse has been escalating in recent years. In 2006, hydrocodone was the most frequently encountered opioid pharmaceutical in drug evidence submitted to the National Forensic Laboratory Information System... In the 2005 Drug Abuse Warning Network combination products were associated with more emergency room visits than any other pharmaceutical opioid with an estimated 51,225 emergency room visits. Poison control data, medical examiners’ reports, and treatment center data all indicate that the abuse of hydrocodone is associated with significant public health risks, including a substantial number of deaths."

More information on the drug can be found here.

hydrocodon_008.jpg

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Fun With Fertility…Or Lack Of It

November 30th, 2007 by admin

As some of you that have been keeping up with my life over the past few years might recall, there has been some attempted baby making going on. These have been futile attempts. Frustration sets in, and more than anything, I get sad. In the beginning phases of baby making, I would freak out if I didnt get the sex when I wanted it. And not just freak out like my previous post regarding the email freak out, but full blown I-am-a-fcking-nutcase freak out. Ah yes, that was back in the day prior to getting on the anxiety candy. Since those days, I am not taking the candy anymore, and I have learned alternate methods to deal with my anxiety. Although, if I wasnt in baby making mode, Id be on the candy in a heartbeat. You can bet your ass that if and when I pop one out, Ill be back on those things once my doc gives me the thumbs up.

So here we areover a year of attempts and no results. Now I will fully admit, there have been months where we just didnt feel like trying. There was some sort of ridiculously stressful situation going on, God knows weve had plenty of those, and we just didnt feel up to it. However, now that things are getting back to normal again, we have been totally proactive with our attempts. I bought the pee tests, or as the doctors like to call it I am practicing the clear plan, around my fertile days to ensure were getting it on during the right time. So far, Ive had the green light for the past several months. I went in for my annual exam, and all was well. I had blood drawn today to test a shit load of stuff such as hormones, ovulation, egg count, etc. TheBoy is going to be getting a semenalysis in the next month to check his junk. And then somewhere during the time between December 12th and 14th, I am going to have a Hysterosalpingogram (HSG) done. I have a read a lot about this HSG thing, and all the professional websites say to take a mild pain killer due to period-like cramping. However, I have also read some message boards with comments from the women who have had this done, and some say it is comparable to labor pains. Some say it is the most excruciating thing they have ever felt. Everyone talks about popping Xanax and pain killers like Valium prior to. Xanax AND Valium??? Needless to say, I am scared shitless.

I never in a million years thought it would be this hard to get pregnant, but my mom said it took over two years to get me. Maybe that is how the women in my family roll? But not really because her mom popped a few out with no issues, and her mother had enough to organize their own damn football team. So this is where I am in regards to babies. TheBoy is scared shitless that if I have to get put on some kind of fertility drug that well end up with octuplets. Im not really worried about that as I think wed probably get twins at the most since they do run on my mothers side. However, with the kind of luck we have, I guess anything is possible.

So I invite you to follow me and my attempted journey to motherhood………CHEESY HUH? Yeah, I thought so, too.

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“Mom! Help! Quick!”

November 30th, 2007 by admin

Nobody wants to hear those words, but that's what I heard tonight.

My son was taking the garbage down to the bottom of the driveway. He loaded it into the back of the pickup truck and the next thing i knew was my phone ringing and my hysterical 16 year old boy crying for me. i asked what happened and he kept saying, "i don't know. hurry."

I ran down, in my pajamas and crocs. There is my son sitting in the truck. door open. engine off. He's crying and shaking. I look around, expecting to see an animal or a huge dent somewhere. There's nothing. Then i look under the truck and there it is. The drive shaft. twisted. broken. hanging down. smelling bad.

"what is THAT?" i asked.

he said he couldn't take his foot off the brake. I said to put it in park but he said it was. the emergency brake was on too and the keys were out, but if he let go of the brake, the truck was going to slide back down the driveway, into the road, and hit the guard rail. (we're on a curve on a mountain road).

I slid in next to him and he slid out while I kept my foot on the brake. He looked and started crying more. he kept saying he didn't do anything, he was just driving up slowly. so i calmed him down enough to help me, because I really didn't know what to do, and he went and got straps to tow with, which he hooked up, then slid back in and kept his foot on the brake while I went and got my truck and hooked it up. then i was able to pull us both up our second driveway enough so that he could slowly let it back down and stop against a fallen tree we dragged into place ahead of time.

we went inside, with me being shaky and my normally super calm son being in tears.

we go inside and I head straight for the xanax, and he heads straight for the cookies i made. apparently, nothing ruins his appetite.

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Almost Done With Lyrica

November 28th, 2007 by admin

I should be completely off of Lyrica by the weekend. It's going well but I was not on the medication that long. I would suspect that withdrawal is tougher the longer you stay on it.

Once I am off everything then I can try, again, the Flexeril and Tramadol, to see if this intense pain can be relieved. I've never had anything like this. I did not sleep very well due to pain and worry. Pain sucks and anxiety sucks too!

I am worried about this pain and my ability to function. I still haven't talked to my employer. I just know they won't make it easier for me. I would not be surprised if they slowed or stopped my career growth. Truth is I could function better from home. The walk to work was torture this morning. My balance is affected as well. So, I'm not very productive.

I will be calling my Doc after I am off Lyrica completely and determine if, some how, this pain was caused by Lyrica. Part of me doesn't want to call anyone. Sometimes, when I am sick and/or in pain I will turn inside and keep to myself and not seek out help. I just keep telling myself that it will pass. Part is from fear. What happens if it doesn't pass? What happens if I have to ask someone for help or for a favor? I don't have reliable assistance until I can move closer to family.

I'm rambling because I'm becoming unnerved about this pain. I need to become a remote worker and my manager's manager knows this. I don't want to be a remote worker right now. The home situation stinks and getting away from it is a good thing. I want to get closer to family and then become a remote worker. But, that's going to take some time. With all of this mess I don't need this kind of pain. But, it's the hand I was dealt and I don't have the answers.

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Torture!

November 28th, 2007 by admin

Holy cow I have never experienced pain like I had yesterday afternoon and today. Most of it is in my legs. The joints and muscles. My ankles are so painful I can hardly walk.

Then, at work, we had an hour long meeting with our new CEO. For the event we got to sit on tiny, un-cushioned, folding chairs. These were the most ungodly horrible chairs I've had the misfortune of sitting in.

Here's what they looked like. 

It's awful and my pain is completely out of control. This is a type of pain I've never experienced before. I'm a bit frightened by its intensity. I haven't called the Doc because he is of the mindset that more drugs will do the trick. Maybe so, but I'm not taking anything until I get Lyrica out of my system. I have to see if some of this was caused by Lyrica. I just started cutting back last night. No, the decreased dose did not cause this. This was full blown yesterday afternoon and after the chair incident it's way over the top.

If I am to have to endure pain like this I'm not sure how I will be able to handle much else. I mean, my energy is so focused on getting a bit of relief I don't have any energy left for anything else life requires.

I don't drive so I walk to and from work.  This is now very difficult to say the least.

Where will this lead? I don't know. I just pray it will pass or become manageable. Remember I have ZERO support at home or even close by. I have to manage this on my own. Today, I am barely managing.

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Lyrica Causes New and More Intense Pain!

November 28th, 2007 by admin

Well it looks like Lyrica is about to bite the dust again. I can't stand the pain that it is causing. It does help the Fibro pain but the hand and foot pain and maddening not to mention the pain it causes when walking. I am having joint pain and other pains in my legs that I've never had or have never had to this intensity before. It seems that Lyrica replaces one pain with another.

I have found other folks that have the same reaction I do. I keep trying and I was excited when Lyrica ridded me of the Fibro pain. But, I am so over it now that I have a new set of pain and it is horrible. I can't sit for very long and I can't walk well enough to enjoy it. I do walk 2 miles a day. I really have to talk to myself to keep going. It's not enjoyable but I do it because there are benefits.

My Doc, the last time I saw him, just wanted to increase my dose. I don't even take the full dose he has prescribed. He wants me to take 150 mg twice a day. I can only take it at night due to the drowsiness effect. I tried to explain to him the extra pain but he just kept telling me it was probably osteoarthritis pain and he would review the notes from the orthopedic surgeon that referred me to him.

Yes, I have osteoarthritis but this is different. It's very disabling and just seems to be getting worse. So, this time I'll wean off of this mess and stay off. I think I'd rather go back to Flexeril and an occasional Tramadol.

 

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Life was never meant to be so painful… Lazaris

November 28th, 2007 by admin

Ending pain... relieving pain... freedom from pain... chronic pain... For years, I suffered from fibromyalgia, a debilitating chronic pain  condition... and I have relieved my symptoms, many of them, most of them... 98%, somewhere in the ballpark... I have written articles about it, and I have been writing a book about it, have interviewed many luminaries about it, and now I am writing a blog about it...  to explore the topic in more depth... will share insights, resources, tools and laughter... joy ... sorrows ...

My story and spiel about the book goes something like this...   In 1996, I was sleepless in Las Vegas. (Now I am sleepless in Carson City, I've migrated)...  In the throes of a painful divorce, I lost my job, home and two cats, was rear-ended in a car accident, and three important family members died. After all of that trauma and stress, I was diagnosed with fibromyalgia. Imagine being told you're going to be in chronic pain for the rest of your life. Bound and determined to find the best experts on the planet to help me stop the pain, I listened to my spiritual guidance, became proactive and found an abundance of support, tools and resources every step of the way. 

All I wanted was to get rid of my aches and pains. But surprise surprise: my quest to get to the center of my pain turned into a journey to the center of my Soul.

Now I have relieved my chronic pain with natural therapies and you can, too. My book, Aching for Love: Relieve Your Chronic Pain Naturally 

offers a unique premise: you can stop chronic pain by reconnecting with 

your Soul. My true-life account combined with the wisdom and 

innovative treatments of numerous leading health care professionals is an 

empowering self-healing workshop in a box. 

 

Another empowering premise of the book is that a majority of people 

suffering from chronic pain also have undiagnosed post-traumatic stress 

disorder, (PTSD) a treatable condition. Yet people with baffling chronic pain conditions 

are routinely told that they have an incurable illness or their pain is 

all in their head. This book offers hope that you, too, can recover your 

life and End the mind-numbing pain.

 

Plus, this may sound too good to be true and hard to believe, but when the 

root cause of your pain is found and relieved, then pain no longer has to 

be managed, contained, borne, coped with or lived with because painful 

symptoms can be treated, alleviated and even eliminated for good!

• Learn self-healing strategies recommended by numerous leading experts: 

techniques such as non-dominant handwriting, guided imagery

visualizations, and yoga-like physical exercises

 

• Survive the PITTS (Poor nutrition, Infection, Trauma, Toxins and 

Stress)

 

• Redefine chronic pain and master its clues

 

• Change, let go and release negative beliefs, stress, attitudes, and 

feelings

 

• Enhance self-love, self-forgiveness, self-pampering and increase 

self-esteem, self-respect, self-worth and self-confidence

 

• Craft and live a pain-free life

 

• Re-connect with your Soul

 

• And Much, Much More

 

 

http://www.inlighttimes.com/archives/2005/08/fibro.htm

 

http://www.healthywealthynwise.com/article.asp?Article=3067

 

I recently spoke with Dr. Jacob Teitelbaum, author of numerous books about fibro and chronic fatigue including Pain 1-2-3... he has a free short form questionnaire on his website vitality101.com that is an invaluable resource for people with fibro, and he is Medical Director of a group of centers that work with people with chronic pain.... I will share about my interview with him in an upcoming post... 

 

For now, here are a few of his websites:

 

http://www.jacobteitelbaum.com/ 

 

http://www.endfatigue.com/tools-support/Online-Program.html

 

(it is called the short program).... it is free, though it may say that it is $88...

 

 http://www.fibroandfatigue.com/



Upcoming posts will include information about cranial sacral therapy, massage, dolphin assisted therapy, EMDR (Eye Movement Desensitization Reprocessing), EFT (Emotional Freedom Technique), the Healing Codes, poems, recommended books and tapes, exercises you can do now, practical tips and other interviews with luminaries, pain experts, best-selling authors such as Dr. T., Dr. John Upledger, Chris Griscom of The Light Institute, Dr. Thomas Shinder, Belle Naparstek, Dr. Doreen Virtue, Dr. Lucia Capacchione and many others.  

 

Enjoy... Come back soon...

 

Soft hugs...  and Angel wings... 

Life was never meant to be so pain... let's make it so !

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